Ken Levine, producenten bakom Bioshock Infinite, har sagt att en ny installation i serien kommer att skapas av Irrational Games först när rätt idé dyker upp. Om idén uteblir kan en annan studio få stå för jobbet. Nedanstående citat kommer från Reddit.
"In terms of more Irrational BioShock games, it's way too early to say. It will ALWAYS be dependent upon us having an idea that we're in love with and excites us. IF we don't have that, I suspect it would be another studio making one, if there was one to make. But I can't imagine doing it if we weren't in love with the idea. I didn't work on Bio 2, so I wouldn't change anything."