För första gången i serien så har Konami lagt till officiella ligor i Pro Evolution Soccer. Till del 4 så har man lagt vantarna på licensen för den holländska, italienska och spanska ligan. Klubbar som Ajax, Real Madrid, Milan och Juventus finns alltså med i spelet.
"We are delighted to add three officially licensed leagues to Pro Evolution Soccer 4. Fans of the game have long called for us to implement their favorite teams in their favorite game, and this marks a major step forward in our quest to deliver the most authentic football title around. Adding all clubs from the Dutch, Spanish, and Italian leagues confirms that we are committed to adding more and more authenticity to the series, and Konami of Europe is confident that further deals with other clubs will follow in the near future." säger Martin Schneider, marknadsföringschef hos Konami Europe.
Spelet släpps i slutet av året till PS2, Xbox och PC.